姓名：艾笑羽

职称：副教授

学科方向：药剂学

招生方向：药物制剂

邮箱：xiaoxixi0818@126.com

通讯地址：必赢电子游戏网站 天津市津南区海河教园同砚路38号 300350

教师简介：

2006年至2010年就读于沈阳药科大学药学（基础药学理科基地班）专业，获得理学学士学位，同年保送研究生进入沈阳药科大学必赢电子游戏网站并直接攻读药剂学博士学位，2015年获药剂学专业博士学位，同年7月就职于必赢电子游戏网站。主要研究方向为药物新剂型与新制剂的研究开发。2010年至2015年参加的研究项目包括国家自然科学基金资助项目“阿霉素聚乙二醇二硬脂酸甘油酯胶束用于肿瘤深部传递的研究”、“阿霉素纳米胶束克服肿瘤多药耐药及促进口服吸收的研究”、“尼莫地平纳米结晶口服吸收机制的研究”和“还原敏感性载体对抗癌药物肿瘤细胞内有效释放的研究”。发表文章九篇，申请专利一项（已授权）。

代表性论文：

1. Star-shape redox-responsive PEG-sheddable copolymer of disulfide-linked polyethylene glycol-lysine-di-tocopherol succinate for tumor-triggering intracellular doxorubicin rapid release: head-to-head comparison. Ai X, Sun J, Zhong L, Wu C, Niu H, Xu T, Lian H, Han X, Ren G, Ding W, Wang J, Pu X, He Z.Macromol Biosci. 2014 Oct;14(10)

2. Thin-film hydration preparation method and stability test of DOX-loaded disulfide-linked polyethylene glycol 5000-lysine-di-tocopherol succinate nanomicelles . Ai X, Zhong L, Niu H, He Z. AJPS, 2014, 9 (5): 244-250 .

3. Nimodipine nanocrystals for oral bioavailability improvement: role of mesenteric lymph transport in the oral absorption.Fu Q, Sun J, Ai X, Zhang P, Li M, Wang Y, Liu X, Sun Y, Sui X, Sun L, Han X, Zhu M, Zhang Y, Wang S, He Z. Int J Pharm. 2013 May 1;448(1):290-7. 

4.Improved oral absorption of doxorubicin by amphiphilic copolymer of lysine-linked ditocopherol polyethylene glycol 2000 succinate: in vitro characterization and in vivo evaluation. Wang J, Li L, Du Y, Sun J, Han X, Luo C, Ai X, Zhang Q, Wang Y, Fu Q, Yang Z, He Z. Mol Pharm. 2015 Feb 2;12(2):463-73.

5. Stealth CD44-targeted hyaluronic acid supramolecular nanoassemblies for doxorubicin delivery: probing the effect of uncovalent pegylation degree on cellular uptake and blood long circulation. Han X, Li Z, Sun J, Luo C, Li L, Liu Y, Du Y, Qiu S, Ai X, Wu C, Lian H, He Z. J Control Release. 2015 Jan 10;197:29-40.

6. Nanomicelles based on X-shaped four-armed peglyated distearylglycerol as long circulating system for doxorubicin delivery. Zhang W, Sun J, Fang W, Ai X, Cai C, Tang Y, Su X, Feng Z, Liu Y, Tao M, Yan X, Chen G, He Z. Eur J Pharm Sci. 2014 Oct 13;66C:96-106. 

7. PEG-stabilized bilayer nanodisks as carriers for doxorubicin delivery. Zhang W, Sun J, Liu Y, Tao M, Ai X, Su X, Cai C, Tang Y, Feng Z, Yan X, Chen G, He Z. Mol Pharm. 2014 Oct 6;11(10):3279-90. 

8.Enhanced oral delivery of paclitaxel using acetylcysteine functionalized chitosan-vitamin E succinate nanomicelles based on a mucus bioadhesion and penetration mechanism.Lian H, Zhang T, Sun J, Liu X, Ren G, Kou L, Zhang Y, Han X, Ding W, Ai X, Wu C, Li L, Wang Y, Sun Y, Wang S, He Z.Mol Pharm. 2013 Sep 3;10(9):3447-58. 

9. Profiling biopharmaceutical deciding properties of absorption of lansoprazole enteric-coated tablets using gastrointestinal simulation technology. Wu C, Sun L, Sun J, Yang Y, Ren C, Ai X, Lian H, He Z. Int J Pharm. 2013 Sep 10;453(2):300-6.