姓名：杨光

职称：副研究员

研究方向：药物化学，有机合成，化学生物学

电子邮件：guang.yang@nankai.edu.cn

教师简介：

杨光，副研究员，2006年在天津大学应用化学专业获得本科学位，2009年硕士毕业于天津大学必赢电子游戏网站药物化学专业。同年10月前往英国格拉斯哥大学（University of Glasgow）化学系攻读博士学位。导师是英国爱丁堡皇家科学院院士（FRSE），化学院院长Prof. J. Stephen Clark。2013年6月获得有机化学博士学位（Ph.D）。然后前往英国诺丁汉大学（University of Nottingham）化学系，合作导师是Dr. Robert Stockman和Prof. Christopher Moody，进行药物化学的博士后训练。期间加入了欧洲药物化学联合发展项目（European IMI），与新药研发企业（Sygnature Discovery）合作，进行新颖母核的合成探索，化合物库的制备与高通量筛选工作，服务于创新药物研发。2014年回到南开大学，进入必赢电子游戏网站，药物化学生物学国家重点实验室，从事复杂天然产物的全合成及其相关药物化学工作。2016年7月加盟必赢电子游戏网站，从事药物化学，化学生物学研究工作。近5年内发表SCI文章30余篇，申请专利20余项，授权15项。

项目组主要研究方向有：

（1）基于结构与构象优化策略，针对重要靶点开展高活性的分子设计、合成、筛选与评价的研究。

（2）天然产物的全合成与半合成结构改造，发现具有重要生物活性（癌症干细胞，免疫调控，代谢调控等）的先导化合物。

（3）小分子活性探针的设计与合成，应用于先导化合物的成药靶点探索与分子机制的确认。

（4）靶向蛋白水解嵌合体（PROTAC）技术的开发及其机制的研究。

（5）手性药物合成方法学与药物分子合成工艺的开发与优化。

（6）候选药物分子的发现与创新药物分子的临床前开发。

代表性论文：

34. Kun Zhang, Wei Song, Mingming Wei, Yue Sun, Ning Wang, Lan Ma, Xuan Yu, Ruolin Gao, Ruonan Wang, Yan Zhang, Nan Zheng, Ning Li, Linrong Mu, Zhiwen Tang, Xuechun Li, Guang Yang* A Novel Anticancer Stem Cell Compound Derived from Pleuromutilin Induced Necroptosis of Melanoma Cells. J. Med. Chem. 2021, 64, 15825−15845.

33. Sheng Cao, Lan Ma, Yulin Liu, Mingming Wei, Yuhong Yao, Chen Li, Ruonan Wang, Ning Liu, Zhiqiang Dong, Xuechun Li, Ming Li, Xiaoji Wang, Guang Yang* Proteolysis-Targeting Chimera (PROTAC) Modification of Dovitinib Enhances the Antiproliferative Effect against FLT3-ITD-Positive Acute Myeloid Leukemia Cells. J. Med. Chem. 2021, 64, 16497−16511.(Cover story)

32. C. Li, Y. Huang, S. Cao, Y. Luo, Y. Zhang and G. Yang A robust and facile method for desulfonation to amines. Org. Chem. Front. 2021, 8, 6182.(Cover story, HOT paper)

31. Mingming Wei, Yunyun Zhou, Chong Li, Yuyu Yang, Tongtong Liu, Yulin Liu, Yujiao Wei,Ning Liu, Shuangwei Liu, Qianqian Wang, Sheng Cao, Yue Sun, Pengzhen Sheng, Cheng Lu, Xiang Liu,* and Guang Yang * 5α-Epoxyalantolactone Inhibits Metastasis of Triple-Negative Breast Cancer Cells by Covalently Binding a Conserved Cysteine of Annexin A2. J. Med. Chem. 2021, 64, 12537−12547.(Cover story)

30. Yujiao Wei, Yanting Tang, Yunyun Zhou, Yuyu Yang, Yetong Cui, Xuan Wang, Yubo Wang, Yulin Liu, Ning Liu, Qianqian Wang, Chong Li, Hao Ruan, Honggang Zhou, Mingming Wei,* Guang Yang,* Discovery and Optimization of a Novel 2H‑Pyrazolo[3,4-d]pyrimidine Derivative as a Potent Irreversible Pan-Fibroblast Growth Factor Receptor Inhibitor. J. Med. Chem. 2021, 64, 9078−9099.

29. Juan Zhang, Xuefeng Gao, Mingming Wei, Yonghui Li, Guang Yang,* Li Yu* A novel epigenetic drug conjugating flavonoid and HDAC inhibitor confer suppression of acute myeloid leukemogenesis. Clinical Science 2021, 135, 1751–1765.

28. Wang, J.; Sun, T.; Meng, Z.; Wang, L.; Li, M.; Chen, J.; Qin, T.; Yu, J.; Zhang, M.; Bie, Z.; Dong, Z.; Jiang, X.; Lin, L.; Zhang, C.; Liu, Z.; Jian, R.; Yang, G.;* Li, L.;* Zhang, Y.;* Huang, D. * XPO1 inhibition synergizes with PARP1 inhibition in small cell lung cancer by targeting nuclear transport of FOXO3a. Cancer Lett. 2021, 503, 197-212.

27. Yubo Wang, Yuanyuan Zhou, Sheng Cao, Yue Sun, Zhiqiang Dong, Chen Li, Haoran Wang, Yuhong Yao, Haiyan Yu, Xiangyi Song, Jiefu Wang, ^* Mingming Wei, ^* Guang Yang ^* In vitro and In vivo degradation of programmed cell death ligand 1 (PD-L1) by a proteolysis targeting chimera (PROTAC). Bioorg. Chem. 2021, 111, 104833.

26. Zhong Weilong, Sun Bo, Ruan Hao, Qian Baoxin, Yang Guang, Cao Hailong, He Lingfei, Fan Yunjing, Roberts Arthur G., Liu Xiang, Hu Xuejiao, Liang Yuan, Ye Qing, Yin Tingting, Wang Bangmao,* Yang Cheng,* Sun Tao,* Zhou Honggang.* Deglycosylated Azithromycin Targets Transgelin to Enhance Intestinal Smooth Muscle Function., iScience, 2020, 23(9): 101464-101472.

25. Wang Xiaoji, Luo Yunhao, Qin Shuanglin, Sun Yue, Wang Ning, Yan Jun,* Yang Guang* Rh-Catalyzed diastereo- and linear-selective alpha-allylation of chiral cycloenamines, Org. Chem. Front., 2020, 7, 3715-3719.

24. Wei Mingming, Zhao Rui, Cao Yuting, Wei Yujiao, Li Ming, Dong Zhiqiang, Liu Yulin, Ruan Hao, Li Ying, Cao Sheng, Tang Zhiwen, Zhou Yuanyuan, Song Wei, Wang Yubo, Wang Jiefu, * Yang Cheng, * Yang, Guang * First orally bioavailable prodrug of proteolysis targeting chimera (PROTAC) degrades cyclin-dependent kinases 2/4/6 in vivo., Eur. J. Med. Chem. 2021, 209, 112903.

23. Wang Jingya, Sun Tao, Meng Zhaoting, Wang Liuchun, Li Mengjie, Chen Jinliang, Qin Tingting, Yu Jiangyong, Zhang Miao, Bie Zhixin, Dong Zhiqiang, Jiang Xiangli, Lin Li, Zhang Cuicui, Liu Zhujun, Jiang Richeng, Yang Guang, * Li Lin, * Zhang Yan, * Huang Dingzhi * XPO1 inhibition synergizes with PARP1 inhibition in small cell lung cancer by targeting nuclear transport of FOXO3a, Can. Lett., 2021, 503, 197-212.

22. Wei Mingming, Xie  Maodun, Zhang Zhen, Wei Yujiao, Zhang Juan, Pan Hongli, Li Benlong, Wang Jingjing, Song Yang, Chong Chuangke, Zhao Rui, Wang Jiefu,* Yu Li,* Yang  Cheng,* Yang, Guang* Design and synthesis of novel Flavone-based histone deacetylase inhibitors antagonizing activation of STAT3 in breast cancer, Eur. J. Med. Chem. 2020, 206, 112677.

21. Mingming Wei, Maodun Xie, Zhen Zhang, Yujiao Wei, Juan Zhang, Hongli Pan, Benlong Li, Jingjing Wang, Yang Song, Chuangke Chong, Rui Zhao, Jiefu Wang,* Li Yu,* Guang Yang,* Cheng Yang* Eur. J. Med. Chem. 2020, 206, 2020, 112677.

20. Shuanglin Qin, Linbin Yao, Yunhao Luo, Tongtong Liu, Jiayuan Xu, Yue Sun, Ning Wang, Jun Yan, Bencan Tang,* Guang Yang,* Cheng Yang* Org. Chem. Front., 2020, 7,3132(Cover Story).

19. Xiaohe Li, Maodun Xie, Cheng Lu, Jiahe Mao, Yuting Cao, Yuyu Yang, Yujiao Wei, Xinhua Liu, Sheng Cao, Yang Song, Junya Peng, Yunyun Zhou, Qiuyan Jiang, Gang Lin, Shuanglin Qin, Min Qi, Min Hou,* Xiang Liu,* Honggang Zhou,* Guang Yang, * Cheng Yang * Eur. J. Med. Chem. 2020, 203, 112614-112624.

18. Shuanglin Qin, Yuting Cao, Yunhao Luo, Shende Jiang, J. Stephen Clark, Xiaoji Wang,* Guang Yang * Helv. Chim. Acta 2019, 102, e1900131.

17. Heng Zhang, Wei-long Zhong, Bo Sun, Guang Yang, Yan-rong Liu, Bi-jiao Zhou, Xin Chen, Xiang-yan Jing, Long-cong Huai, Ning Liu, Zhi-yuan Zhang, Mi-mi Li, Jing-xia Han, Kai-liang Qiao,Jing Meng, Hong-gang Zhou,* Shuang Chen,* Cheng Yang,* and Tao Sun* iScience, 2019, 21, 549–561.

16. Shuanglin Qin, Tongtong Liu, Yunhao Luo, Jun Yan, Hong Kang, Shende Jiang*, Guang Yang* Synlett 2019, ASAP, DOI: 10.1055/s-0037-1611718

15. Shuanglin Qin, Tongtong Liu, Yunhao Luo, Shende Jiang and Guang Yang* Org. Chem. Front. 2019, ASAP, DOI: 10.1039/c8qo01258j.

14. Shaoyu Liu, Hui Ma, Zhanwen Zhang, Liping Lin, Gongjun Yuan, Xiaolan Tang, Dahong Nie,Shende Jiang, Guang Yang*, Ganghua Tang* Theranostics 2019, ASAP, Doi: 10.7150/thno.29405.

13. Yuan Qin, Hui-juan Liu, Meng Li, Deng-hui Zhai, Yuan-hao Tang, Lan Yang, Kai-liang Qiao, Jia-huan Yang, Wei-long Zhong, Qiang Zhang, Yan-rong Liu, Guang Yang*, Tao Sun*,  EBioMed. 2018, 38, 25-36.

12. Xinhua Liu, Benlong Li, Zhen Zhang, Yujiao Wei, Zhongxin Xu, Shuanglin Qin, Ning Liu, Rui Zhao, Junya Peng, Guang Yang, Min Qi, Tongtong Liu, Maodun Xie, Shuangwei Liu, Xian Gao, Cheng Lu, Lijun Zhu, Xinyu Long, Hong Kang, Tao Sun, Honggang Zhou, Mingming Wei,* Guang Yang* J. Med. Chem. 2018, 61, 10814-10833.

11. Xiaohe Li, Cheng Lu, Shuangwei Liu, shuaishuai Liu, Chengcheng Su, Ting Xiao, Zhun Bi, Pengzhen Sheng, Mengying Huang, Xinhua Liu, Yujiao Wei, Lin Zhao, Shengxiang Miao, Jiahe Mao, Kai Huang, Shaoyan Gao, Ning Liu, Min Qi, Tongtong Liu, Shuanglin Qin, Luqing Wei, Tao Sun, Wen Ning, Guang Yang,* Honggang Zhou,*  Eur. J. Med. Chem. 2018, 156, 229-247.

10. Shuangwei Liu, Xian Gao, Lisong Zhang, Shuanglin Qin, Mingming Wei, Ning Liu, Rui Zhao, Benlong Li, Ye Meng, Gang Lin, Cheng Lu, Xinhua Liu, Maodun Xie, Tongtong Liu, Honggang Zhou, Min Qi,* Guang Yang,*  Eur. J. Med. Chem. 2018, 156, 21-42.

9. Shuanglin Qin, Shuangwei Liu, Yuting Cao, Jiangnan Li, Chuanke Chong, Tongtong Liu, Yunhao Luo, Jiyun Hu, Shende Jiang, Honggang Zhou, Guang Yang*  Org. Lett. 2018, 20, 1350-1354.

8. Yuan Qin, Guang Yang, Meng Li, Hui-juan Liu, Wei-long Zhong, Xueqin Yan, Kai-liang Qiao, Jia-huan Yang, Deng-hui Zhai, Wei Yang, Shuang Chen, Hong-gang Zhou, Tao Sun*  Oncotarget, 2018, 8, 103815-103827

7. Jinghan Wang, Beijia Kuang, Xiaoqian Guo, Jianwei Liu, Yahui Ding, Jiangnan Li, Shende Jiang, Ying Liu, Fang Bai, Luyuan Li, Quan Zhang, Xiao-Yu Zhu, Bo Xia, Chun-Qi Li, Liang Wang,* Guang Yang,* and Yue Chen* J. Med. Chem. 2017, 60, 1189-1209.

6. Jiangnan Li, Shende Jiang, George Procopiou, Robert A. Stockman,* and Guang Yang* Eur. J. Org. Chem. 2016, 3500-3504.

5. Zhantao Yang, Guang Yang,* Meiyan Ma, Jiangnan Li, Jianwei Liu, Jinghan Wang, Shende Jiang, Quan Zhang, and Yue Chen* Org. Lett. 2015, 17, 5725-5727.

4. Feng Sang, Yahui Ding, Jinghan Wang, Bingxia Sun, Jianlei Sun, Yan Geng, Zhang Zhang, Ke Ding, Ling-Ling Wu, Jian-Wei Liu, Cuigai Bai, Guang Yang,* Quan Zhang,* Lu-Yuan Li,* and Yue Chen* J. Med. Chem. 2016, 59, 1184-1196.

3. Sang, F.; Li, D.; Sun, X.; Cao, X.; Wang, L.; Sun, J.; Sun, B.; Wu, L.; Yang, G.; Chu, X.; Wang, J.; Dong, C.; Geng, Y.; Jiang, H.; Long, H.; Chen, S.; Wang, G.; Zhang, S.; Zhang, Q.; Chen, Y.* J. Am. Chem. Soc. 2014, 136, 15787;

2. Clark, J. S.*; Yang, G.; Osnowski, A. P. Org. Lett. 2013, 15, 1464;

1. Clark, J. S.*; Yang, G.; Osnowski, A. P. Org. Lett. 2013, 15, 1460;