姓名：孟萌

职称：教授

电子邮箱：mengmeng@nankai.edu.cn

联系地址：天津市津南区同砚路38号必赢电子游戏网站315

学科方向：药剂学

课程讲授：《药物发展简史》（本科），《生化分析与分子诊断》（本科），药剂学综合试验（本科），《学术规范及论文写作指导》（研究生）

研究方向：

1. 近红外荧光及光声成像体系在药物设计和疾病诊断中的应用

2. 有机光热/光动力治疗分子的合成及功能调试

3. 疾病微环境响应型纳米制剂

教育经历：

2003年9月–2008年7月, 北京大学必赢电子游戏网站，药剂学, 博士，导师：张强教授

1999年9月–2003年7月, 北京大学必赢电子游戏网站，药学, 本科

工作经历：

2022年12月-至今 必赢电子游戏网站，教授

2010年12月-2022年12月，必赢电子游戏网站, 副教授

2017年10月-2018年10月, 美国加州大学洛杉矶分校, 访问学者，合作导师：Prof. Hsian-Rong Tseng

2008年7月-2010年12月, 必赢电子游戏网站，讲师

教师简介：

课题组主要从事有机发光分子的设计、纳米递送及其在成像指导的药物设计和疾病诊疗等方面研究。通过调试分子的光敏特性和生物学效应，初步开展药效学评价和药代动力学研究，以发展具有开发前景的临床前候选成像、光疗分子或递送体系。

以第一作者或通讯作者在J. Am. Chem. Soc.，Small，Chem. Eng. J.，J. Control. Release, ACS AMI, Anal. Chem.等杂志上发表文章30余篇。承担了国家自然科学基金面上项目、国家自然科学金青年项目和天津市自然科学基金等项目，作为研究骨干参与了科技部国际合作项目和国家863项目。教育部学位中心学位论文（抽检）评审专家，Angew. Chem.和Adv. Mater.等多个期刊审稿人。

近五年学术论文：

1. Xiujie Zhao, Hongjie Zhao, Shuo Wang, Zhiwen Fan, Yan Ma, Yongmei Yin, Wei Wang, Rimo Xi,* and Meng Meng*, A Tumor-Targeting Near-Infrared Heptamethine Cyanine Photosensitizer with Twisted Molecular Structure for Enhanced Imaging-Guided Cancer Phototherapy, J. Am. Chem. Soc. 2021, 143, 20828−20836.

2. Bei Wang, Qi Gan, Yue Tong, Yanqi Qiao, Mengfan Han, Ruixiao Zhang, Quansheng Han, Chuanbing Li, Su Bai, Long Xu, Yongmei Yin, Chunze Zhang, Baatar Munkhtsetseg, Xiujie Zhao*, Meng Meng*, Rimo Xi,* A visual diagnostic detection of Helicobacter pylori and the gastric carcinoma-related virulence genes (cagA and vacA) by a fluorescent loop-mediated isothermal amplification (LAMP), Talanta 256 (2023) 124260.

3. Yanqi Qiao, Yan Ma, Yue Tong, Wenting Liu, Shuo Wang, Ying Zheng, Changjun Men, Jie Yu, Jie Pan, Dong Wan, Yongmei Yin, Xiujie Zhao,* Rimo Xi,* and Meng Meng*, Phototherapy and Mechanism Exploration of Biofilm and Multidrug-Resistant Helicobacter pylori by Bacteria-Targeted NIR Photosensitizer, Small 2022, 2205248.

4. Shuo Wang, Yueping Bai, Dayuan Wang, Yunqian Zhai, Yanqi Qiao, Xiujie Zhao, Yongmei Yin, Rimo Xi, Wei Wang, Wei Zhao*, Meng Meng*, Reversing tumor to “Hot”: A NIR light-triggered carrier-free nanoplatform for enhanced tumor penetration and photo-induced immunotherapy, Chem. Eng. J. 442 (2022) 136322.

5. Xiujie Zhao,*§ Shuo Wang § Yan Ma, Wenting Liu, Hongjie Zhao, Jianhao Di, Zhiwen Fan, Yongmei Yin, Ying Zheng, Rimo Xi,* and Meng Meng*, Synergistic Release of Photothermal Molecules from Nanocarriers Induced by Light and Hyperthermia Benefits Efficient Anticancer Phototherapy, Anal. Chem. 2022, 94, 17160−17168 (§ X.Z. and S.W. contributed equally to this work).

6. Dening Gu, Yanqi Qiao, Hongli Fu, Hongjie Zhao, Xinmin Yue, Shuo Wang, Yongmei Yin, Rimo Xi, Xiaoling Fu,* Xiujie Zhao,* and Meng Meng*, Size-Controllable DNA Origami-Stacked Gold Nanoparticles for Deep Tumor-Penetrating Therapy, ACS Appl. Mater. Interfaces 2022, 14, 33, 38048–38055.

7. Xinmin Yue, Yanqi Qiao, Dening Gu, Rui Qi, Hongjie Zhao, Yongmei Yin, Wei Zhao, Rimo Xi,* and Meng Meng*, DNA-Based pH Nanosensor with Adjustable FRET Responses to Track Lysosomes and pH Fluctuations, Anal. Chem. 2021, 93, 7250−7257.

8. Kai Wang, Ruixiao Zhang, Xinmin Yue, Zheng Zhou, Lihuan Bai, Yue Tong, Bei Wang, Dening Gu, Shuo Wang, Yanqi Qiao, Qian Liu, Xue Xue, Yongmei Yin, Rimo Xi*, Meng Meng*, Synthesis of Diboronic Acid-Based Fluorescent Probes for the Sensitive Detection of Glucose in Aqueous Media and Biological Matrices, ACS Sens. 2021, 6, 1543−1551.

9. Yanqi Qiao, Qingqing Xue, Xinmin Yue, Yang Liu, Qian Liu, Xiujie Zhao, Dening Gu, Shuo Wang, Kai Wang, Yongmei Yin, Jing Li, Rimo Xi*, Meng Meng*, A DNA nanoscaffold-based electrochemical assay for sensitive determination of O-GlcNAc transferase (OGT) activity and its application in cell-permeable OGT inhibitors screening, Sensors Actuat. B-Chem. 334 (2021) 129665.

10. Shuo Wang, Zengyi Liu, Yue Tong, Yunqian Zhai, Xiujie Zhao, Xinmin Yue, Yanqi Qiao, Yonghui Liu, Yongmei Yin, Rimo Xi, Wei Zhao*, Meng Meng*, Improved cancer phototheranostic efficacy of hydrophobic IR780 via parenteral route by association with tetrahedral nanostructured DNA, J. Control. Release 330 (2021) 483–492.

11. Xiujie Zhao, Zhiwen Fan, Yanqi Qiao, Yun Chen, Shuo Wang, Xinmin Yue, Tangliang Shen, Wenting Liu, Jie Yang, Heqi Gao, Xuelin Zhan, Luqing Shang, Yongmei Yin, Wei Zhao, Dan Ding, Rimo Xi*, Meng Meng*, AIEgens Conjugation Improves the Photothermal Efficacy and Near-Infrared Imaging of Heptamethine Cyanine IR-780, ACS Appl. Mater. Interfaces 2020, 12: 16114–16124.

12. Xiujie Zhao, Yun Chen, Guiyu Niu, Dening Gu, Jianning Wang, Yanmei Cao, Yongmei Yin, Xiaogang Li, Dan Ding, Rimo Xi* and Meng Meng*, Photostable pH-Sensitive Near-Infrared Aggregation-Induced Emission Luminogen for Long-Term Mitochondrial Tracking, ACS Appl. Mater. Interfaces, 2019, 11: 13134–13139.

13. Xinmin Yue, Yanqi Qiao, Dening Gu, Zixuan Wu, Wenhui Zhao, Xiaoyu Li, Yongmei Yin, Wei Zhao, Deming Kong, Rimo Xi*, Meng Meng*, Reliable FRET-ON imaging of telomerase in living cells by a tetrahedral DNA nanoprobe integrated with structure-switchable molecular beacon, Sensors Actuat. B-Chem. 2020, 312, 127943.

14. Wei Liu, Wenxiu Yu, Xiaogang Li, Xiaoyong Zhao, Yu Zhang, Pei Song, Yongmei Yin, Rimo Xi, Meng Meng*, Pyrophosphate-triggered intermolecular cross-linking of tetraphenylethylene molecules for multianalyte detection, Sensors Actuat. B-Chem., 2018, 266:170–177.

15. Li Xiaogang#, Liu Wei#, Yue Xinmin, Song Pei, Yin Yongmei, Meng Meng*, Xi Rimo*, A competitive immunoassay using hapten-modified polydiacetylene vesicles for homogeneous and sensitive detection of sodium benzoate, Sensors Actuat. B-Chem., 2018, 258: 1060–1065.

授权专利情况：

1. 孟萌，王朔，赵炜，佟悦，刘增艺，翟芸芊，郗日沫，一种花菁类光敏剂核酸纳米聚集体的制备及应用，南开大学，CN202010574254.X.

2. 孟萌，赵秀杰，郗日沫，陈韵，邓川，一种具有PTT效应及聚集诱导发光增强效应的近红外荧光探针的制备，南开大学，ZL 201911345771.3.

3. 孟萌，赵秀杰，郗日沫，陈韵，王建宁，曹彦梅，一种具有聚集诱导发光效应的线粒体靶向型近红外荧光探针的制备，南开大学，ZL 201910010982.5.